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About House, M.D.

House, also known as House, M.D., was a critically-acclaimed American medical drama television series created by David Shore and executively produced by film director Bryan Singer. The Emmy and Peabody award-winning medical drama debuted on the FOX Network on November 16, 2004, and aired its last episode on May 21, 2012.

For eight years the show brought in people from around the globe, bringing intrigue and mystery in the form of unusual medical cases in a vein reminiscent of the mysteries solved by Sherlock Holmes. Furthermore, these cases were the catalyst for the discussion of philosophical and ethical issues and decisions, a lot of which were not left with a clear victor, but all of which revealed more and more of the character of each of the different doctors that comprised the team each year. In the end, while the team didn’t completely understand (or appreciate) House’s methods fully, the show gives a final hurrah as each of the members walks away with something they realize was the right thing to do after all. Although the mantra “Everybody Lies” is proven over and over again, the concept that “people never change, they only come up with better lies” is tested up until the last moments as the characters (and the show) drive off into an adventure left to the imagination.

Everything is challenged, nothing is sacred, and the most profound revelations of life can be found within the 172 hours of television given over the course of the eight seasons of pill-popping, dripping sarcasm, dark humor, and intelligent storytelling ever to grace the small screen of the living room (or large screen, if that may be the case, but then…everybody lies). This wiki is intended for your perusal to catch up, read, make new or more complete connections on various subject matter, or perhaps relive the funny if outrageous times given to us by actor Hugh Laurie and company.

Enjoy!

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RhabdoUrine

Rhabdomyolysis

Rhabdomyolysis or “Rhabdo” is a condition in which damaged skeletal muscle breaks down rapidly. Symptoms may include myalgia, weakness, vomiting, and confusion. There may be tea-colored urine or an arrythmia. Some of the muscle breakdown products, such as the protein myoglobin, are harmful to the kidneys and may lead to kidney failure.

The muscle damage is most often the result of Crush syndrome, strenuous exercise, Pharmaceuticals, or drug abuse. Other causes include infections, electrical injury, heat stroke, prolonged immobilization, limb ischemia, or snake bites. Some people have genetic muscle conditions that increase the risk of rhabdomyolysis. The diagnosis is supported by a urine test strip which is positive for “blood” but the urine contains no red blood cells when examined with a microscope. Blood tests show a creatine kinase greater than 1,000 U/L, with severe disease being above 5,000 U/L.

The mainstay of treatment is large quantities of intravenous fluids. Other treatments may include dialysis or blood filtratiom in more severe cases. Once urine output is established sodium bicarbonate and mannitol are commonly used but they are poorly supported by the evidence. Outcomes are generally good if treated early. Complications may include hyperkalemia, hypocalcemia, disseminated intravascular coagulation, and compartment syndrome.

Rhabdomyolysis occurs in about 26,000 people a year in the United States. While the condition has been commented on throughout history, the first modern description was following an earthquake in 1908. Important discoveries as to its mechanism were made during the Blitz of London in 1941. It is a significant problem for those injured in earthquakes and relief efforts for such disasters often include medical teams equipped to treat survivors with rhabdomyolysis.

Signs and symptoms

The symptoms of rhabdomyolysis depend on its severity and whether kidney failure develops. Milder forms may not cause any muscle symptoms, and the diagnosis is based on abnormal blood tests in the context of other problems. More severe rhabdomyolysis is characterized by myalgia, tenderness, weakness and edema of the affected muscles. If the swelling is very rapid, as may happen with a crush injury after someone is released from under heavy collapsed debris, the movement of fluid from the bloodstream into damaged muscle may cause low blood pressure and shock. Other symptoms are nonspecific] and result either from the consequences of muscle tissue breakdown or from the condition that originally led to the muscle breakdown. Release of the components of muscle tissue into the bloodstream causes electrolyte disturbances, which can lead to nausea, vomiting, confusion, coma or arrhythmia. The urine may be dark, often described as “tea-colored”, due to the presence of myoglobin. Damage to the kidneys may give rise to decreased or absent urine productio, usually 12 to 24 hours after the initial muscle damage.

Swelling of damaged muscle occasionally leads to compartment syndrome—compression of surrounding tissues, such as nerves and blood vessels, in the same fascial compartment —leading to the loss of blood supply and damage or loss of function in the part(s) of the body supplied by these structures. Symptoms of this complication include pain or reduced sensation in the affected limb. A second recognized complication is disseminated intravascular coagulation (DIC), a severe disruption in coagulation that may lead to uncontrollable bleeding.

Causes

Any form of muscle damage of sufficient severity can cause rhabdomyolysis. Multiple causes can be present simultaneously in one person. Some have an underlying muscle condition, usually hereditary in nature, that makes them more prone to rhabdomyolysis.
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House: “Is this hell? An eternity of people trying to convince me to live?
Cameron: “Who says I’m here to convince you to live?
―Cameron’s hallucination appears in Everybody Dies

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